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MONDAY, 10 SEPTEMBER, 2007 (Concurrent Sessions WFN & IHA)
Hall 1, Hall 4 and Meeting Room 1
8:30-10:30
Scientific Session I: Pathogenesis and Pathophysiology of HD I
Chairs:Marcy MacDonald (Boston, USA), Stefano Di Donato (Milan, Italy)
08:30Shooting the Messenger: siRNA as Treatment in HD?
Beverly Davidson (Iowa City, USA)
09:00Somatic Triplet Repeat Mutation Length Gains in HD Tissues – Relevant for HD?
Gillian P. Bates (London, UK)
09:10Multiple, Structurally and Functionally Distinct Aggregates in Peptide and Cell Models of Huntingtin Exon-1 Behaviour
Ron Wetzel (Pittsburgh, USA)
09:30Polyglutamine: Structural Properties and Toxicity Threshold
Yvon Trottier (Strasbourg, France)
09:50Crystal Structure of the Central Coiled-Coil Domain of Huntingtin-Interacting Protein 1 (HIP1) Reveals a Potential Binding Surface for Huntingtin and HIPPI
Joel A. Ybe (Bloomington, USA)
10:00Chaperones, Neurodegeneration and Chaperonotherapy
Sarah Broadley (Martinsried, Germany)
10:20Identification of Novel Non-Canonical Chaperones of the Hsp40 Family as Very Potent Suppressors of Polyglutamine Proteins in Cell Models and In Vivo Xenopus Model
Harm H. Kampinga (Groningen, The Netherlands)
Clinical Session I: Understanding the Clinical Features of HD
Chairs:Julie Snowden (Manchester, UK), Matthias Dose (Taufkirchen, Germany)
08:30Understanding Basal Ganglia Dysfunction in HD
Anne B. Young (Boston, USA)
09:00Psychopathology in Huntington’s Disease Gene Carriers in Comparison with their Gene-Negative Siblings and the General Population
Erik van Duijn (Leiden, The Netherlands)
09:15Emotion Recognition in Huntington’s Disease
Julie Snowden (Manchester, UK)
09:30Emotion Recognition and its MRI Correlates: Selective Impairment of Anger Recognition in Huntington’s Disease
Susie Henley (London, UK)
09:40Predicting Depression in Pre-HD
Kevin Duff (Iowa, USA)
09:50Obsessive and Compulsive Symptoms in Pre-Diagnosed Huntington’s Disease
Leigh J. Beglinger (Iowa, USA)
10:00Irritability in Presymptomatic Huntington’s Disease
Stefan Klöppel (London, UK)
10:10Behaviour Change in Huntington’s Disease Focused on Aggression
Markus Alexander Lindinger (Graz, Austria)
10:20Clinical Presentation and Biological Changes in Juvenile Huntington’s Disease: Evidence of Dosage Effect of the Mutation
Ferdinando Squitieri (Pozzilli, Italy)
IHA Session I
Chair:Catherine Paradise (Dublin, Ireland)
08:30How People with HD Think, how to Accommodate these Changes and how to More Efficiently Interact with those whom you Love (Part I)
James J. Pollard (Lowell, USA)

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